Spiropyrrolizidine Analogues of Rosuvastatin from <i>N</i>‐(4‐(4‐Fluorophenyl)‐5‐formyl‐6‐isopropylpyrimidin‐2‐yl)‐N‐methylmethanesulfonamide-Reference-Cited by-同舟云学术

Spiropyrrolizidine Analogues of Rosuvastatin from N‐(4‐(4‐Fluorophenyl)‐5‐formyl‐6‐isopropylpyrimidin‐2‐yl)‐N‐methylmethanesulfonamide

Published:2023-08-23 Issue:32 Volume:8 Page:
ISSN:2365-6549
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Author:

Gorli Venkata Nookaapparao¹,Srinivasan Rajagopal²

Affiliation:

1. Bio-Organic Laboratory Organic & Bio-Organic Division CSIR-Central Leather Research Institute (CSIR-CLRI) Sardar Patel Road Adyar Chennai 600 020 INDIA.

2. Bio-Organic Laboratory Organic & Bio-Organic Division CSIR-CLR Communication Number: 1843 CSIR-Central Leather Research Institute (CSIR-CLRI) Sardar Patel Road Adyar Chennai 600 020 India

Abstract

AbstractA series of spiropyrrolizidine analogues have been synthesized through 1,3‐dipolar cycloaddition of an azomethine ylide generated from isatin and L‐proline with dipolarophile which is prepared from Rosuvastatin intermediate N‐(4‐(4‐fluorophenyl)‐5‐formyl‐6‐isopropylpyrimidin‐2‐yl)‐N‐methylmethanesulfonamide and acetophenones. The stereochemistry of the cycloadduct was assigned based on the single‐crystal X‐ray structure.

Funder

Central Leather Research Institute

Publisher

Wiley

Subject

General Chemistry

Reference23 articles.

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4. The Huisgen Reaction: Milestones of the 1,3‐Dipolar Cycloaddition

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