Mammalian peroxidases activate anticancer drug ellipticine to intermediates forming deoxyguanosine adducts in DNA identical to those foundin vivo and generated from 12-hydroxyellipticine and 13-hydroxyellipticine-Reference-Cited by-同舟云学术

Mammalian peroxidases activate anticancer drug ellipticine to intermediates forming deoxyguanosine adducts in DNA identical to those foundin vivo and generated from 12-hydroxyellipticine and 13-hydroxyellipticine

Published:2006 Issue:2 Volume:120 Page:243-251
ISSN:0020-7136
Container-title:International Journal of Cancer
language:en
Short-container-title:Int. J. Cancer

Author:

Stiborová Marie,Poljaková Jitka,Ryšlavá Helena,Dračínský Martin,Eckschlager Tomáš,Frei Eva

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference53 articles.

1. The anticancer agent ellipticine on activation by cytochrome P450 forms covalent DNA adducts☆1☆Supported by German Cancer Research Center, Grant Agency of the Czech Republic (grant 203/01/0996) and the Ministry of Education of the Czech Republic (grant MSM 1131 00001).1Abbreviations: α-NF, α-naphthoflavone; 3-IPMDIA, 3-isopropenyl-3-methyldiamantane; CHAPS, 3-[(3-cholamidopropyl)-dimethylammonio]-1-propane sulfonate; CYP, cytochrome P450; IC50, 50% inhibitory dose; MDR, multidrug resistance; PEI, polyethylenimine; RAL, relative adduct labeling; TLC, thin-layer chromatography

2. Multimodal action of antitumor agents on DNA: The ellipticine series

3. High-Field NMR and Restrained Molecular Modeling Studies on a DNA Heteroduplex Containing a Modified Apurinic Abasic Site in the Form of Covalently Linked 9-Aminoellipticine

4. Ellipticine increase the superhelical density of intracellular SV40 DNA by intercalation

5. DNA-drug recognition and effects on topoisomerase II-mediated cytotoxicity. A three-mode binding model for ellipticine derivatives

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