Mechanisms responsible for the altered pharmacokinetics of Bosentan: analysis utilizing rats with bile duct ligation-induced liver dysfunction

Author:

Horiuchi Isao,Mori Yun-i,Taguchi Masato,Ichida Fukiko,Miyawaki Toshio,Hashimoto Yukiya

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology,General Medicine

Reference23 articles.

1. Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist;Clozel;J Pharmacol Exp Ther,1994

2. Absorption, excretion, and metabolism of the endothelin receptor antagonist bosentan in healthy male subjects;Weber;Drug Metab Dispos,1999

3. Clinical pharmacology of bosentan, a dual endothelin receptor antagonist;Dingemanse;Clin Pharmacokinet,2004

4. Single- and multiple-dose pharmacokinetics of bosentan and its interaction with ketoconazole;Van Giersbergen;Br J Clin Pharmacol,2002

5. Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A;Shitara;J Pharmacol Exp Ther,2003

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