Development and validation of UFLC–MS/MS method for determination of bosentan in rat plasma

Author:

Atila Alptug,Ozturk Murat,Kadioglu Yucel,Halici Zekai,Turkan Didar,Yayla Muhammed,Un Harun

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference16 articles.

1. Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist;Clozel;J. Pharmacol. Exp. Ther.,1994

2. Endothelin receptor antagonists;Motte;Pharmacol. Ther.,2006

3. Warfarin and bosentan interaction in a patient with pulmonary hypertension secondary to bilateral pulmonary emboli;Spangler;Clin. Ther.,2010

4. TracleerTM (bosentan) Product Information, Actelion Pharmaceuticals. Available from , 2011.

5. Absorption, excretion, and metabolism of the endothelin receptor antagonist bosentan in healthy male subjects;Weber;Drug Metab. Dispos.,1999

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