Prediction of the Pharmacokinetics of Pravastatin as an OATP Substrate Using Plateable Human Hepatocytes With Human Plasma Data and PBPK Modeling
Author:
Affiliation:
1. Department of Drug Metabolism and PharmacokineticsGenentech, A Member of the Roche GroupSouth San Francisco California USA
2. In Vitro ADMET Laboratories Inc. (IVAL)Columbia Maryland USA
Funder
Genentech
Publisher
Wiley
Subject
Pharmacology (medical),Modelling and Simulation
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/psp4.12283
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3. Clinical Pharmacokinetics of Pravastatin
4. Human liver‐specific organic anion transporter, LST‐1, mediates uptake of pravastatin by human hepatocytes;Nakai D.;J. Pharmacol. Exp. Ther.,2001
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