Epimer interconversion, isomerization, and hydrolysis of tetrahydrouridine: Implications for cytidine deaminase inhibition

Author:

Xiang Tian‐Xiang,Niemi Riku,Bummer Paul,Anderson Bradley D.

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference37 articles.

1. Nucleic acids. IV. The catalytic reduction of pyrimidine nucleosides (human liver deaminase inhibitors);Hanze;J Am Chem Soc,1967

2. Five‐chlorodeoxycytidine and biomodulators of its metabolism result in fifty to eighty percent cures of advanced EMT‐6 tumors when used with fractionated radiation;Greer;Int J Radiat Oncol Biol Phys,1995

3. Potent inhibitors for the deamination of cytosine arabinoside and 5‐aza‐2′‐deoxycytidine by human cytidine deaminase;Laliberte;Cancer Chemother Pharmacol,1992

4. Tetrahydrouridine: Physiologic disposition and effect upon deamination of cytosine arabinoside in man;Kreis;Cancer Treat Rep,1977

5. Phase I evaluation of tetrahydrouridine combined with cytosine arabinoside;Wong;Cancer Treat Rep,1979

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