Synthesis of [1‐ 13 C‐5‐ 12 C]‐alpha‐ketoglutarate enables noninvasive detection of 2‐hydroxyglutarate-Reference-Cited by-同舟云学术

Synthesis of [1‐ 13 C‐5‐ 12 C]‐alpha‐ketoglutarate enables noninvasive detection of 2‐hydroxyglutarate

Published:2021-07-14 Issue:11 Volume:34 Page:
ISSN:0952-3480
Container-title:NMR in Biomedicine
language:en
Short-container-title:NMR in Biomedicine

Author:

Miura Natsuko¹,Mushti Chandrasekhar²,Sail Deepak²,AbuSalim Jenna E.¹³,Yamamoto Kazutoshi⁴,Brender Jeffrey R.⁴,Seki Tomohiro⁴,AbuSalim Deyaa I.⁵,Matsumoto Shingo⁴,Camphausen Kevin A.¹,Krishna Murali C.⁴,Swenson Rolf E.²,Kesarwala Aparna H.¹³^ORCID

Affiliation:

1. Radiation Oncology Branch National Cancer Institute, National Institutes of Health Bethesda Maryland USA

2. Chemistry and Synthesis Center, National Heart, Lung, and Blood Institute National Institutes of Health Bethesda Maryland USA

3. Department of Radiation Oncology, Winship Cancer Institute Emory University School of Medicine Atlanta Georgia USA

4. Radiation Biology Branch National Cancer Institute, National Institutes of Health Bethesda Maryland USA

5. Department of Chemistry Indiana University Bloomington Indiana USA

Funder

Japan Society for the Promotion of Science

National Cancer Institute

Publisher

Wiley

Subject

Spectroscopy,Radiology, Nuclear Medicine and imaging,Molecular Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/nbm.4588

Reference35 articles.

1. α-Ketoglutarate links p53 to cell fate during tumour suppression

2. Alpha-Ketoglutarate: Physiological Functions and Applications

3. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

4. L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH

5. Lactate Dehydrogenase C Produces S-2-Hydroxyglutarate in Mouse Testis

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