L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH-Reference-Cited by-同舟云学术

L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH

Published:2017-03-06 Issue:5 Volume:13 Page:494-500
ISSN:1552-4450
Container-title:Nature Chemical Biology
language:en
Short-container-title:Nat Chem Biol

Author:

Intlekofer Andrew M,Wang Bo,Liu Hui,Shah Hardik^ORCID,Carmona-Fontaine Carlos,Rustenburg Ariën S,Salah Salah,Gunner M R,Chodera John D,Cross Justin R,Thompson Craig B

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology

Link

http://www.nature.com/articles/nchembio.2307.pdf

Reference62 articles.

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3. Dang, L. et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 462, 739–744 (2009).

4. Ward, P.S. et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting α-ketoglutarate to 2-hydroxyglutarate. Cancer Cell 17, 225–234 (2010).

5. Figueroa, M.E. et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell 18, 553–567 (2010).

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