Safety, pharmacokinetics, and activity of EZN-2208, a novel conjugate of polyethylene glycol and SN38, in patients with advanced malignancies

Author:

Kurzrock Razelle,Goel Sanjay,Wheler Jennifer,Hong David,Fu Siqing,Rezai Keyvan,Morgan-Linnell Sonia K.,Urien Saik,Mani Sridhar,Chaudhary Imran,Ghalib Mohammed H.,Buchbinder Aby,Lokiec François,Mulcahy Mary

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference20 articles.

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3. Pharmacokinetics, metabolism, and excretion of irinotecan (CPT-11) following IV infusion of [C]CPT-11 in cancer patients;Slatter;Drug Metab Dispos.,2000

4. Bioactivation of the anticancer agent CPT-11 to SN-38 by human hepatic microsomal carboxylesterases and the in vitro assessment of potential drug interactions;Slatter;Drug Metab Dispos.,1997

5. Pharmacokinetics of irinotecan and its metabolites in human blood, bile, and urine;Lokiec;Cancer Chemother Pharmacol.,1995

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