Chemotherapy resistant Burkitt lymphoma: Possible novel therapies including CAR‐T cell infusion

Author:

Geerts Paulus A. F.1ORCID,’t Hart Nils2,Visser Otto1,Ortiz‐Maldonado Valentín3,Chamuleau Martine E. D.4

Affiliation:

1. Department of Internal Medicine Isala Klinieken Zwolle Netherlands

2. Department of Pathology Isala Klinieken Zwolle Netherlands

3. Department of Hematology Hospital Clínic de Barcelona Barcelona Spain

4. Department of Hematology Amsterdam University Medical Centre Amsterdam Netherlands

Abstract

Key Clinical MessageThe prognosis of patients with relapsed or refractory (R/R) BL is poor with limited response to salvage therapy, especially for patients with early relapse (<6 months) or refractory disease. Novel therapies may be promising but need refinement.AbstractThe prognosis of patients with relapsed or refractory (R/R) BL is poor with a limited response to salvage therapy, especially for patients with early relapse (<6 months) or refractory disease. We present three cases of patients with R/R BL receiving novel therapies followed by a literature review. Amongst others, the patients received inotuzumab ozogamicin, idelalisib, ibrutinib, and CAR‐T cell therapy, however, with limited response. In literature, response to several novel agents is described; however, most promising results are seen with CAR‐T cell therapy. Concluding from case series, sequential CAR‐T cell therapy, targeting multiple B‐cell antigens, seems most promising.

Publisher

Wiley

Subject

General Medicine

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