Pharmacokinetic Drug‐Drug Interaction Study of Omecamtiv Mecarbil With Amiodarone and Digoxin in Healthy Subjects
Author:
Affiliation:
1. Amgen Inc Thousand Oaks California USA
2. Covance Inc Madison Wisconsin USA
Publisher
Wiley
Subject
Pharmacology (medical),Pharmaceutical Science
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpdd.1028
Reference22 articles.
1. Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure
2. Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil
3. Direct Myosin Activation by Omecamtiv Mecarbil for Heart Failure with Reduced Ejection Fraction
4. Improvement of Cardiac Function by a Cardiac Myosin Activator in Conscious Dogs With Systolic Heart Failure
5. Omecamtiv Mecarbil Modulates the Kinetic and Motile Properties of Porcine β-Cardiac Myosin
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1. Mechanism-based inactivation of cytochromes P450: implications in drug interactions and pharmacotherapy;Xenobiotica;2024-08-28
2. Omecamtiv Mecarbil in the treatment of heart failure: the past, the present, and the future;Frontiers in Cardiovascular Medicine;2024-03-19
3. Novel Treatments of Hypertrophic Cardiomyopathy in GDMT for Heart Failure: A State-of-art Review;Current Problems in Cardiology;2023-09
4. Small molecule drugs to improve sarcomere function in those with acquired and inherited myopathies;American Journal of Physiology-Cell Physiology;2023-07-01
5. A deleterious interaction between omecamtiv mecarbil and atrial fibrillation in patients with heart failure: an influence of digoxin?;European Heart Journal;2022-04-20
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