Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure-Reference-Cited by-同舟云学术

Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure

Published:2011-03-18 Issue:6023 Volume:331 Page:1439-1443
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Malik Fady I.¹,Hartman James J.¹,Elias Kathleen A.¹,Morgan Bradley P.¹,Rodriguez Hector¹,Brejc Katjuša¹,Anderson Robert L.¹,Sueoka Sandra H.¹,Lee Kenneth H.¹,Finer Jeffrey T.¹,Sakowicz Roman¹,Baliga Ramesh¹,Cox David R.¹,Garard Marc¹,Godinez Guillermo¹,Kawas Raja¹,Kraynack Erica¹,Lenzi David¹,Lu Pu Ping¹,Muci Alexander¹,Niu Congrong¹,Qian Xiangping¹,Pierce Daniel W.¹,Pokrovskii Maria¹,Suehiro Ion¹,Sylvester Sheila¹,Tochimoto Todd¹,Valdez Corey¹,Wang Wenyue¹,Katori Tatsuo²,Kass David A.²,Shen You-Tang³⁴,Vatner Stephen F.³⁵,Morgans David J.¹

Affiliation:

1. Preclinical Research and Development, Cytokinetics, Inc., South San Francisco, CA 94080, USA.

2. Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA.

3. CV Dynamics, North Brunswick, NJ 08902, USA.

4. Department of Medicine and Division of Cardiovascular Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

5. Department of Cell Biology and Molecular Medicine, and Cardiovascular Research Institute, New Jersey Medical School, University of Medicine and Dentistry, New Jersey, Newark, NJ 07103, USA.

Abstract

A small molecule improves cardiac function by accelerating the transition of myosin into a force-producing state.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Link

http://www.sciencemag.org/content/331/6023/1439.full.pdf

Reference24 articles.

1. Executive Summary: Heart Disease and Stroke Statistics—2010 Update