Comparison of different protein precipitation and solid‐phase extraction protocols for the study of the catabolism of peptide drugs by LC‐HRMS-Reference-Cited by-同舟云学术

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Comparison of different protein precipitation and solid‐phase extraction protocols for the study of the catabolism of peptide drugs by LC‐HRMS

Published:2020-07-06 Issue:9 Volume:26 Page:
ISSN:1075-2617
Container-title:Journal of Peptide Science
language:en
Short-container-title:J Pep Sci

Author:

Esposito Simone¹,Vanni Domitilla²,Menta Sergio¹,Orsatti Laura¹^ORCID,Monteagudo Edith¹

Affiliation:

1. ADME/DMPK DepartmentIRBM S.p.A., Pomezia Rome Italy

2. Department of Chemical Sciences and TechnologiesTor Vergata University of Rome Rome Italy

Publisher

Wiley

Subject

Organic Chemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,General Medicine,Biochemistry,Structural Biology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/psc.3272

Reference18 articles.

1. Peptide and protein drugs: The study of their metabolism and catabolism by mass spectrometry

2. Strategic Approaches to Optimizing Peptide ADME Properties

3. An efficient liquid chromatography-high resolution mass spectrometry approach for the optimization of the metabolic stability of therapeutic peptides

4. A liquid chromatography high-resolution mass spectrometry in vitro assay to assess metabolism at the injection site of subcutaneously administered therapeutic peptides

5. Software-aided approach to investigate peptide structure and metabolic susceptibility of amide bonds in peptide drugs based on high resolution mass spectrometry

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1. The high-throughput solid-phase extraction of cis-cyclo(L-Leu-L-Pro) and cis-cyclo(L-Phe-L-Pro) from Lactobacillus plantarum demonstrates efficacy against multidrug-resistant bacteria and influenza A (H3N2) virus;Frontiers in Molecular Biosciences;2024-05-17

2. Method Development and Validation for Simultaneous Detection of Corticosteroids, Small Peptides, SARMs and Quaternary Ammonium Drugs in Camel Urine for Doping Control Applications;Current Analytical Chemistry;2024-01

3. 4-Aminobenzoic acid, 2-phenoxyethanol and iodine used as tracers in a short-term in vivo-kinetics study for tattoo ink ingredients: Mass spectrometry method development and validation;Journal of Chromatography B;2023-09

4. Subcutaneous catabolism of peptide therapeutics: bioanalytical approaches and ADME considerations;Xenobiotica;2022-08-03

5. Automated high-throughput in vitro assays to identify metabolic hotspots and protease stability of structurally diverse, pharmacologically active peptides for inhalation;Journal of Pharmaceutical and Biomedical Analysis;2022-03

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