Esculentoside A suppresses breast cancer stem cell growth through stemness attenuation and apoptosis induction by blocking IL-6/STAT3 signaling pathway

Author:

Liu Chuanlan1,Dong Lihua2,Sun Zhen1ORCID,Wang Li1,Wang Qiaoping1,Li Haiyan1,Zhang Jie1,Wang Xiujie1ORCID

Affiliation:

1. Laboratory of Experimental Oncology, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, West China Clinical Medical School; Sichuan University; Chengdu 610041 China

2. Human Anatomy Department, School of Preclinical and Forensic Medcine; Sichuan University; Chengdu 610041 China

Funder

Research Foundation of Science and Technology Bureau of Sichuan Province, China

Publisher

Wiley

Subject

Pharmacology

Reference61 articles.

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2. Koenimbin, a natural dietary compound of Murraya koenigii (L) Spreng: Inhibition of MCF7 breast cancer cells and targeting of derived MCF7 breast cancer stem cells (CD44(+)/CD24(-/low)): An in vitro study;Ahmadipour;Drug Design, Development and Therapy,2015

3. Response of estrogen eceptor-positive breast cancer tumorspheres to antiestrogen treatments;Ao;PLoS One,2011

4. Breast cancer stem-like cells are inhibited by diosgenin, a steroidal saponin, by the attenuation of the Wnt β-catenin signaling via the Wnt antagonist secreted frizzled related protein-4;Bhuvanalakshmi;Frontiers in Pharmacology,2017

5. Esculentoside A inhibits LPS-induced acute kidney injury by activating PPAR-γ;Chen;Microbial Pathogenesis,2017

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