Phase I study of PF‐04895162, a Kv7 channel opener, reveals unexpected hepatotoxicity in healthy subjects, but not rats or monkeys: clinical evidence of disrupted bile acid homeostasis-Reference-Cited by-同舟云学术

Phase I study of PF‐04895162, a Kv7 channel opener, reveals unexpected hepatotoxicity in healthy subjects, but not rats or monkeys: clinical evidence of disrupted bile acid homeostasis

Published:2019-02 Issue:1 Volume:7 Page:e00467
ISSN:2052-1707
Container-title:Pharmacology Research & Perspectives
language:en
Short-container-title:Pharmacol Res Perspect

Author:

Aleo Michael D.¹^ORCID,Aubrecht Jiri²,D. Bonin Paul³,Burt Deborah A.²,Colangelo Jennifer²,Luo Lina²,Schomaker Shelli²,Swiss Rachel⁴,Kirby Simon⁵,C. Rigdon Greg⁶,Dua Pinky⁷

Affiliation:

1. Investigative Toxicology Drug Safety Research and Development Pfizer Inc. Groton Connecticut

2. Safety Biomarkers Drug Safety Research and Development Pfizer Inc. Groton Connecticut

3. Medicine Design Primary Pharmacology Group Pfizer Inc. Groton Connecticut

4. Compound Safety Prediction Worldwide Medicinal Chemistry Pfizer Inc. Groton Connecticut

5. Global Biometrics and Data Management Pfizer Inc. Cambridge UK

6. Neusentis Research Unit Pfizer Inc. Durham North Carolina

7. Clinical Pharmacology Early Clinical Development Pfizer Inc. Cambridge UK

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,Neurology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/prp2.467

Reference52 articles.

1. ACG Clinical Guideline: The Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury

2. Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump

3. Setting Clinical Exposure Levels of Concern for Drug-Induced Liver Injury (DILI) Using Mechanisticin vitroAssays

4. In Vitro Approach to Assess the Potential for Risk of Idiosyncratic Adverse Reactions Caused by Candidate Drugs

5. The significance of mitochondrial toxicity testing in drug development

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