Affiliation:
1. Department of Toxicology and Sanitary Chemistry School of Public Health Capital Medical University Beijing 100069 China
2. Beijing Key Laboratory of Environmental Toxicology Capital Medical University Beijing 100069 China
3. Department of Occupational Health and Environmental Health School of Public Health Capital Medical University Beijing 100069 China
4. School of Public Health Shenzhen University Medical School Shenzhen University Shenzhen 518060 China
5. Department of Nephrology Affiliated Beijing Chaoyang Hospital of Capital Medical University Beijing 100020 China
Abstract
AbstractGiven the inevitable human exposure owing to its increasing production and utilization, the comprehensive safety evaluation of silica nanoparticles (SiNPs) has sparked concerns. Substantial evidence indicated liver damage by inhaled SiNPs. Notwithstanding, few reports focused on the persistence or reversibility of hepatic injuries, and the intricate molecular mechanisms involved remain limited. Here, rats are intratracheally instilled with SiNPs in two regimens (a 3‐month exposure and a subsequent 6‐week recovery after terminating SiNPs administration) to assess the hepatic effects. Nontargeted lipidomics revealed alterations in lipid metabolites as a contributor to the hepatic response and recovery effects of SiNPs. In line with the functional analysis of differential lipid metabolites, SiNPs activated oxidative stress, and induced lipid peroxidation and lipid deposition in the liver, as evidenced by the elevated hepatic levels of ROS, MDA, TC, and TG. Of note, these indicators showed great improvements after a 6‐week recovery, even returning to the control levels. According to the correlation, ROC curve, and SEM analysis, 11 lipids identified as potential regulatory molecules for ameliorating liver injury by SiNPs. Collectively, the work first revealed the reversibility of SiNP‐elicited hepatotoxicity from the perspective of lipidomics and offered valuable laboratory evidence and therapeutic strategy to facilitate nanosafety.
Funder
National Natural Science Foundation of China
Subject
General Materials Science,General Chemistry