1. Department of Pharmaceutical Manufacturing Chemistry; Kyoto Pharmaceutical Universit; 1 Shichono-cho, Misasagi, Yamashina-ku Kyoto 606-8414 Japan
2. Medicinal Organic Chemistry Lab.; College of Pharmaceutical Sciences; Ritsumeikan University; 1-1-1 Noji-higashi, Kusatsu Shiga 525-8577 Japan