Combined DNA methylation and gene expression profiling in gastrointestinal stromal tumors reveals hypomethylation ofSPP1as an independent prognostic factor

Author:

Haller Florian1,Zhang Jitao David2,Moskalev Evgeny A.1,Braun Alexander3,Otto Claudia3,Geddert Helene4,Riazalhosseini Yasser5,Ward Aoife2,Balwierz Aleksandra2,Schaefer Inga-Marie6,Cameron Silke7,Ghadimi B. Michael8,Agaimy Abbas1,Fletcher Jonathan A.9,Hoheisel Jörg5,Hartmann Arndt1,Werner Martin3,Wiemann Stefan210,Sahin Özgür2

Affiliation:

1. Institute of Pathology; Friedrich Alexander University; Erlangen-Nuremberg Germany

2. Division of Molecular Genome Analysis; German Cancer Research Center; Heidelberg Germany

3. Institute of Pathology; Albert Ludwigs University; Freiburg Germany

4. Institute of Pathology; St. Vincentius Hospital; Karlsruhe Germany

5. Division of Functional Genome Analysis; German Cancer Research Center; Heidelberg Germany

6. Institute of Pathology; Georg August University; Göttingen Germany

7. Department of Gastroenterology and Endocrinology; Georg August University; Göttingen Germany

8. Department of General and Visceral Surgery; Georg August University; Göttingen Germany

9. Department of Pathology; Brigham and Women's Hospital; Boston MA

10. Genomics and Proteomics Core Facility; German Cancer Research Center; Heidelberg Germany

Funder

DKFZ International PhD Program, Wilhelm Sander-Stiftung

National Genome Research Network of the Federal Ministry of Education and Research (BMBF)

Publisher

Wiley

Subject

Cancer Research,Oncology

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