Epigenetics and field cancerization as the caveats of carcinogenesis and recurrence of gastrointestinal malignancies: a systematic review and meta-analysis protocol-Reference-Cited by-同舟云学术

Epigenetics and field cancerization as the caveats of carcinogenesis and recurrence of gastrointestinal malignancies: a systematic review and meta-analysis protocol

Published:2023-04-01 Issue:2 Volume:2023 Page:
ISSN:2752-616X
Container-title:Journal of Surgical Protocols and Research Methodologies
language:en
Short-container-title:

Author:

Kyaruzi Victor Meza¹^ORCID,Mduma Emmanuel²,Abdelhammed Ahmed³,Suvvari Tarun Kumar⁴,de Dieu Tumusifu Manegabe Jean⁵,Davis Banturaki⁶,Sakaiwa Neontle⁷,Hammoud Zeinab⁸,Tango Tamara⁹,Djatche Wesley Harrisson Bouche¹⁰,Phiri Emmanuel Chileshe¹¹,Tunde Olobatoke¹²,Waffa Zuraiha¹³,Ngamba Ramadhani¹⁴,Elamin Zobidah Yousif¹⁵,Akilimali Aymar¹⁶,Kambey Piniel Alphayo¹⁷,Khamisi Ramadhani¹⁸,Mwanga Ally¹⁸,Shimber Emnet Tesfaye¹⁹,Mfinanga Sayoki²⁰,Mwakigonja Amos²¹,Dodgion Christopher²²

Affiliation:

1. Muhimbili University of Health and Allied Sciences Department of Surgery, School of Medicine, , Dar es Salaam, Tanzania

2. Rabininsia Memorial Hospital Department of Clinical Oncology, , Dar es Salaam , Tanzania

3. University of Al-Azhar Faculty of Medicine, , Cairo , Egypt

4. Department of Surgery, Rangaraya Medical College , Kakinada , India

5. Catholic University of Bukavu Department of Surgery, School of Medicine, , Bukavu, South-Kivu, D.R . Congo

6. Makerere University College of Health Sciences, , Kampala , Uganda

7. University of Botswana School of Medicine, , Gaborone, Selebi Phikwe , Botswana

8. Lebanese University School of Medicine, , Beirut , Lebanon

9. Universitas Indonesia Faculty of Medicine, , Jakarta Pusat , Indonesia

10. Shanxi Medical University School of International Education, , Jinzhong, Shanxi , China

11. Copperbelt University School of Medicine, , Ndola , Zambia

12. University of Lagos College of Medicine, , Lagos , Nigeria

13. Alexandria University Faculty of Medicine, , Alexandria , Egypt

14. National Institute for Medical Research Genomics Department, , Dar es Salaam , Tanzania

15. Omdurman Islamic University Department of Histopathology and Cytology, , Khartoum , Sudan

16. Official University of Bukavu Faculty of Medicine, , Bukavu, South-Kivu, D.R . Congo

17. Xuzhou Medical University Department of Anatomy and Neurobiology, , Jiangsu , China

18. Muhimbili University of Health and Allied Sciences Department of Surgery, School of Medicine, , Dar es Salaam , Tanzania

19. Hawassa University Department of Critical Care and Emergency Medicine, , Awasa , Ethiopia

20. Department of Surgery, National Institute for Medical Research , Dar es Salaam , Tanzania

21. Muhimbili University of Health and Allied Sciences Department of Pathology, School of Medicine, , Dar es Salaam , Tanzania

22. Medical College of Wisconsin Department of Surgery, Division of Trauma and Critical Care, , Milwaukee, WI , USA

Abstract

Abstract Gastrointestinal malignancies constitute the most common neoplasms with increasing prevalence worldwide, which portend a dismal morbidity and higher mortality rate. Epigenetic phenotypes and field cancerization impute a cutting edge for precursor of several gastrointestinal malignancies; this genetic aberration has been implicated in tumorigenesis and recurrence of gastrointestinal malignancies. This systematic review aims at assessing the effect of epigenetics and field cancerization on carcinogenesis and recurrence of gastrointestinal malignancies. This systematic review and meta-analysis will administer the provisions of Preferred Reporting Items for Systematic Review and Meta-analysis 2020 guideline, and the review protocol has been registered at PROSPERO. The literature search will be executed through several electronic databases including EMBASE, PubMed, Scopus, Web of Science, Cochrane, Global Index Medicus, Semantic Scholar and Google Scholar. All original research articles reporting on the effect of epigenetic signatures, epigenetics and field cancerization on the carcinogenesis and recurrence of gastrointestinal cancers in adults will be included. Only articles with Newcastle–Ottawa Scale score above 4 and low risk of bias based on D1–D5 for randomized controlled trials will be included for a meta-analysis. There is no involvement of human subject participation in this review, thus giving no effect to ethical clearance approval. The evidence report of this review will be disseminated on scientific conferences and will be published to a reputable journal of gastroenterology oncology. This review has been registered at PROSPERO registry ID CRD 42023391339.

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/jsprm/article-pdf/2023/2/snad005/50045672/snad005.pdf

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