Targeting a Large Active Site: Structure‐Based Design of Nanomolar Inhibitors of Trypanosoma brucei Trypanothione Reductase-Reference-Cited by-同舟云学术

Targeting a Large Active Site: Structure‐Based Design of Nanomolar Inhibitors of Trypanosoma brucei Trypanothione Reductase

Published:2019-08-13 Issue:49 Volume:25 Page:11416-11421
ISSN:0947-6539
Container-title:Chemistry – A European Journal
language:en
Short-container-title:Chem. Eur. J.

Author:

De Gasparo Raoul¹,Halgas Ondrej²³^ORCID,Harangozo Dora¹,Kaiser Marcel⁴⁵,Pai Emil F.²³^ORCID,Krauth‐Siegel R. Luise⁶,Diederich François¹^ORCID

Affiliation:

1. Laboratorium für Organische ChemieETH Zurich Vladimir-Prelog-Weg 3 8093 Zurich Switzerland

2. Departments of Biochemistry and Medical BiophysicsUniversity of Toronto Medical Sciences Building, 5318, 1 King's College Circle Toronto ON M5S 1A8 Canada

3. The Campbell Family Institute for Cancer ResearchUniversity Health Network 101 College Street Toronto ON M5G 1L7 Canada

4. Swiss Tropical and Public Health Institute Socinstrasse 57 4002 Basel Switzerland

5. University of Basel Petersplatz 1 4003 Basel Switzerland

6. Biochemie-Zentrum Heidelberg (BZH)Universität Heidelberg Im Neuenheimer Feld 328 69120 Heidelberg Germany

Funder

Deutsche Forschungsgemeinschaft

Natural Sciences and Engineering Research Council of Canada

Publisher

Wiley

Subject

General Chemistry,Catalysis,Organic Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/chem.201901664

Reference61 articles.

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3. Management of trypanosomiasis and leishmaniasis

4. GBD 2015 Disease and Injury Incidence and Prevalence Collaborators Lancet2016 388 1545–1602 https://doi.org/10.1016/S0140-6736(16)31678-6;

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