A Guanidyl‐Based Bivalent Peptidomimetic Inhibits K‐Ras Prenylation and Association with c‐Raf-Reference-Cited by-同舟云学术

A Guanidyl‐Based Bivalent Peptidomimetic Inhibits K‐Ras Prenylation and Association with c‐Raf

Published:2019-09-09 Issue:59 Volume:25 Page:13531-13536
ISSN:0947-6539
Container-title:Chemistry – A European Journal
language:en
Short-container-title:Chem. Eur. J.

Author:

Tsubamoto Mai¹,Le Toan Khanh²,Li Minghua³,Watanabe Taku⁴,Matsumi Chiemi⁴,Parvatkar Prakash⁵,Fujii Hiroshi²,Kato Nobuo¹,Sun Jiazhi³,Ohkanda Junko²^ORCID

Affiliation:

1. The Institute of Scientific Industrial ResearchOsaka University 8-1 Mihogaoka Ibaraki Osaka 567-0047 Japan

2. Academic Assembly, Institute of AgricultureShinshu University 8304 Minami-Minowa, Kami-Ina Nagano 399-4598 Japan

3. Department of Pharmaceutical ScienceUniversity of South Florida Tampa Florida 33612 USA

4. Ina LaboratoryMedical & Biological Laboratories, CO., Ltd. Ina Nagano 396-0002 Japan

5. Institute for Chemical ResearchKyoto University, Gokasho Uji Kyoto 611-0011 Japan

Funder

Japan Society for the Promotion of Science

Ministry of Education, Culture, Sports, Science and Technology

Nagase Science Technology Foundation

Astellas Foundation for Research on Metabolic Disorders

Naito Foundation

Uehara Memorial Foundation

Publisher

Wiley

Subject

General Chemistry,Catalysis,Organic Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/chem.201903129

Reference49 articles.

1. KRAS Mutation Status Is Predictive of Response to Cetuximab Therapy in Colorectal Cancer

2. Drugging the undruggable RAS: Mission Possible?

3. In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction

4. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

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