Synthesis of C12‐Keto Saxitoxin Derivatives with Unusual Inhibitory Activity Against Voltage‐Gated Sodium Channels-Reference-Cited by-同舟云学术

Synthesis of C12‐Keto Saxitoxin Derivatives with Unusual Inhibitory Activity Against Voltage‐Gated Sodium Channels

Published:2020-02-03 Issue:9 Volume:26 Page:2025-2033
ISSN:0947-6539
Container-title:Chemistry – A European Journal
language:en
Short-container-title:Chem. Eur. J.

Author:

Adachi Kanna¹,Yamada Tomoshi²,Ishizuka Hayate¹,Oki Mana¹,Tsunogae Shunsuke²,Shimada Noriko²,Chiba Osamu²,Orihara Tatsuya¹,Hidaka Masafumi²,Hirokawa Takatsugu³⁴⁵,Odagi Minami¹,Konoki Keiichi²,Yotsu‐Yamashita Mari²,Nagasawa Kazuo¹^ORCID

Affiliation:

1. Department of Biotechnology and Life Science Faculty of Technology Tokyo University of Agriculture and Technology 2-24-16 Naka-cho Koganei Tokyo 184-8588 Japan

2. Graduate School of Agriculture Science Tohoku University 468-1 Aramaki-Aza-Aoba, Aoba-ku Sendai 980-8572 Japan

3. Transborder Medical Research Center University of Tsukuba 1-1-1 Tennodai Tsukuba 305-8575 Japan

4. Division of Biomedical Science University of Tsukuba 1-1-1 Tennodai Tsukuba 305-8575 Japan

5. Molecular Profiling Research Center for Drug Discovery National Institute of Advanced Industrial Science and Technology 2-4-7 Aomi, Koto-ward Tokyo 135-0064 Japan

Funder

Japan Agency for Medical Research and Development

Publisher

Wiley

Subject

General Chemistry,Catalysis,Organic Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/chem.201904184

Reference74 articles.

1. Differential Modulation of Sodium Channel Gating and Persistent Sodium Currents by the β1, β2, and β3 Subunits

2. International Union of Pharmacology. XLVII. Nomenclature and Structure-Function Relationships of Voltage-Gated Sodium Channels

4. A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel

5. Differences in Saxitoxin and Tetrodotoxin Binding Revealed by Mutagenesis of the Na+ Channel Outer Vestibule

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