Aruncin B: Synthetic Studies, Structural Reassignment and Biological Evaluation
Author:
Affiliation:
1. Department of Chemistry; University of Oxford, Chemistry Research Laboratory; Mansfield Road Oxford OX1 3TA UK
2. Department of Oncology; University of Oxford, Old Road Campus Research Building; Oxford OX3 7DQ UK
Funder
FP7 Research infrastructures
Cancer Research UK
Publisher
Wiley
Subject
General Chemistry,Catalysis,Organic Chemistry
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/chem.201702949/fullpdf
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1. Targeting the Bcl-2 family for cancer therapy
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3. Induction of microtubule-damage, mitotic arrest, Bcl-2 phosphorylation, Bak activation, and mitochondria-dependent caspase cascade is involved in human Jurkat T-cell apoptosis by aruncin B from Aruncus dioicus var. kamtschaticus
4. Total Synthesis and Structural Revision of the Cytotoxin Aruncin B
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