Effects of Tenapanor on Cytochrome P450-Mediated Drug-Drug Interactions

Author:

Johansson Susanne1,Rosenbaum David P.2,Ahlqvist Marie1,Rollison Helen3,Knutsson Mikael1,Stefansson Bergur1,Elebring Marie1

Affiliation:

1. AstraZeneca Gothenburg; Mölndal Sweden

2. Ardelyx Inc., Fremont; CA USA

3. AstraZeneca R&D; Cambridge UK

Funder

AstraZeneca

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science

Reference21 articles.

1. Defective jejunal and colonic salt absorption and altered Na+/H+ exchanger 3 (NHE3) activity in NHE regulatory factor 1 (NHERF1) adaptor protein-deficient mice;Broere;Pflugers Arch.,2009

2. Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins;Orlowski;J Biol Chem.,1992

3. Cloning and sequencing of a rabbit cDNA encoding an intestinal and kidney-specific Na+/H+ exchanger isoform (NHE-3);Tse;J Biol Chem.,1992

4. Intestinal inhibition of the Na+/H+ exchanger 3 prevents cardiorenal damage in rats and inhibits Na+ uptake in humans;Spencer;Sci Transl Med.,2014

5. A phase 1 study of the safety, tolerability, pharmacodynamics, and pharmacokinetics of tenapanor in healthy Japanese volunteers;Johansson;Clin Exp Nephrol.,2016

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