Intestinal Inhibition of the Na + /H + Exchanger 3 Prevents Cardiorenal Damage in Rats and Inhibits Na + Uptake in Humans-Reference-Cited by-同舟云学术

Intestinal Inhibition of the Na + /H + Exchanger 3 Prevents Cardiorenal Damage in Rats and Inhibits Na + Uptake in Humans

Published:2014-03-12 Issue:227 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Spencer Andrew G.¹,Labonte Eric D.¹,Rosenbaum David P.¹,Plato Craig F.²,Carreras Christopher W.¹,Leadbetter Michael R.¹,Kozuka Kenji¹,Kohler Jill¹,Koo-McCoy Samantha¹,He Limin¹,Bell Noah¹,Tabora Jocelyn¹,Joly Kristin M.²,Navre Marc¹,Jacobs Jeffrey W.¹,Charmot Dominique¹

Affiliation:

1. Ardelyx Inc., Fremont, CA 94555, USA.

2. Plato BioPharma Inc., Westminster, CO 80021, USA.

Abstract

An inhibitor of intestinal NHE3 reduces absorption of dietary sodium in rats and humans and prevents salt-induced cardiorenal injury in nephrectomized rats.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference66 articles.

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3. Biology of Human Sodium Glucose Transporters

4. Molecular biology of Na+ absorption.;Barbry P.;Am. J. Physiol.,1997

5. Subcloning, localization, and expression of the rat intestinal sodium-hydrogen exchanger isoform 8

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