Liquid chromatography/quadrupole time-of-flight mass spectrometry in combination with online hydrogen/deuterium exchange technique for structural elucidation of phase I metabolites ofiso-phenylcyclopentylamine in rat bile

Author:

Liu Xiaoxue1,Wang Suilou1,Ding Li1,Chen Xiaoping2,Shen Wenbin3,Dong Xin4,Yun Changhong1,Lin Hongda1

Affiliation:

1. Department of Pharmaceutical Analysis; China Pharmaceutical University; 24 Tongjiaxiang Nanjing 210009 China

2. Beijing Shiqiao Biological and Pharmaceutical Co. Ltd; Beijing China

3. Center for instrumental analysis; China Pharmaceutical University; 24 Tongjiaxiang Nanjing 210009 China

4. State Key Laboratory of Natural Medicines; China Pharmaceutical University; Nanjing 21009 China

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference25 articles.

1. Identification of novel metoclopramide metabolites in humans: in vitro and in vivo studies;Argikar;Drug Metabolism and Disposition,2010

2. Chen XP When SM Shi YY Zhao F Sun ZG Ding H Meng XP Zhang JQ Aryl-cyclobutyl compounds as slimming agents and their preparation, pharmaceutical compositions and use in the treatment of adiposity 2010

3. Systematic LC/MS metabolite identification in drug discovery;Clarke;Analytical Chemistry,2001

4. Metabolite identification of triptolide by data-dependent accurate mass spectrometric analysis in combination with online hydrogen/deuterium exchange and multiple data-mining techniques;Du;Rapid Communication in Mass Spectrometry,2011

5. Detection and characterization of ticlopidine conjugates in rat bile using high-resolution mass spectrometry: applications of various data acquisition and processing tools;Du;Journal of Mass Spectrometry,2013

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