Soluble tau aggregates, not large fibrils, are the toxic species that display seeding and cross-seeding behavior-Reference-Cited by-同舟云学术

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Soluble tau aggregates, not large fibrils, are the toxic species that display seeding and cross-seeding behavior

Published:2018-10-19 Issue:11 Volume:27 Page:1901-1909
ISSN:0961-8368
Container-title:Protein Science
language:en
Short-container-title:Protein Science

Author:

Ghag Gaurav¹²,Bhatt Nemil¹²,Cantu Daniel V.¹²,Guerrero-Munoz Marcos J.¹²,Ellsworth Anna¹²,Sengupta Urmi¹²,Kayed Rakez¹²

Affiliation:

1. Mitchell Center for Neurodegenerative Diseases; University of Texas Medical Branch; Galveston Texas 77555

2. Department of Neurology; University of Texas Medical Branch; Galveston Texas 77555

Funder

National Institutes of Health

Gillson Longenbaugh Foundation

Mitchell Center for Neurodegenerative Diseases

Publisher

Wiley

Subject

Molecular Biology,Biochemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/pro.3499/fullpdf

Reference55 articles.

1. Tau-mediated neurodegeneration in Alzheimer's disease and related disorders;Ballatore;Nat Rev Neurosci,2007

2. The role of tau in neurodegeneration;Gendron;Mol Neurodegener,2009

3. Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms;Andorfer;J Neurochem,2003

4. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model;Yoshiyama;Neuron,2007

5. Caspase activation precedes and leads to tangles;Calignon;Nature,2010

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2. Inhibition of Calcineurin with FK506 Reduces Tau Levels and Attenuates Synaptic Impairment Driven by Tau Oligomers in the Hippocampus of Male Mouse Models;International Journal of Molecular Sciences;2024-08-22

3. MAPT mutations associated with familial tauopathies lead to formation of conformationally distinct oligomers that have cross‐seeding ability;Protein Science;2024-08-15

4. “Prion-like” seeding and propagation of oligomeric protein assemblies in neurodegenerative disorders;Frontiers in Neuroscience;2024-08-05

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