A selective sigma-2 receptor ligand antagonizes cocaine-induced hyperlocomotion in mice

Author:

Lever John R.123,Miller Dennis K.45,Green Caroline L.4,Fergason-cantrell Emily A.12,Watkinson Lisa D.12,Carmack Terry L.12,Fan Kuo-hsien6,Lever Susan Z.67

Affiliation:

1. Research Service, Harry S. Truman Memorial Veterans' Hospital; Columbia Missouri 65201

2. Department of Radiology and Radiopharmaceutical Sciences Institute; University of Missouri; Columbia Missouri 65211

3. Department of Medical Pharmacology and Physiology; University of Missouri; Columbia Missouri 65211

4. Department of Psychological Sciences; University of Missouri; Columbia Missouri 65211

5. Center for Translational Neuroscience, School of Medicine; University of Missouri; Columbia Missouri 65211

6. Department of Chemistry; University of Missouri; Columbia Missouri 65211

7. MU Research Reactor Center; University of Missouri; Columbia Missouri 65212

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience

Reference63 articles.

1. S2RPgrmc1: The cytochrome-related sigma-2 receptor that regulates lipid and drug metabolism and hormone signaling;Ahmed;Expert Opin Drug Metab Toxicol,2012

2. In vivo neurobiological effects of ibogaine and its O-desmethyl metabolite, 12-hydroxyibogamine (noribogaine), in rats;Baumann;J Pharmacol Exp Ther,2001

3. Selective labeling of the dopamine transporter by the high affinity ligand 3β-(4-[125I]Iodophenyl)tropane-2 β-carboxylic acid isopropyl ester;Boja;Mol Pharm,1995

4. CB-64D and CB-184: Ligands with high sigma 2 receptor affinity and subtype selectivity;Bowen;Eur J Pharmacol,1995

5. Relationship between the inhibition constant (Ki) and the concentration of inhibitor which causes 50 per cent inhibition (IC50) of an enzymatic reaction;Cheng;Biochem Pharmacol,1973

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