Breast cancer risk in BRCA1/2 mutation carriers and noncarriers under prospective intensified surveillance

Author:

Engel Christoph1ORCID,Fischer Christine2,Zachariae Silke1,Bucksch Karolin1,Rhiem Kerstin3,Giesecke Jutta3,Herold Natalie3,Wappenschmidt Barbara3,Hübbel Verena3,Maringa Monika3,Reichstein‐Gnielinski Simone3,Hahnen Eric3ORCID,Bartram Claus R.2,Dikow Nicola2,Schott Sarah4,Speiser Dorothee5,Horn Denise6,Fallenberg Eva M.7,Kiechle Marion8,Quante Anne S.8,Vesper Anne‐Sophie9,Fehm Tanja9,Mundhenke Christoph10,Arnold Norbert11,Leinert Elena12,Just Walter13,Siebers‐Renelt Ulrike14,Weigel Stefanie15,Gehrig Andrea16,Wöckel Achim17,Schlegelberger Brigitte18,Pertschy Stefanie19,Kast Karin202122,Wimberger Pauline202122,Briest Susanne23,Loeffler Markus1,Bick Ulrich7,Schmutzler Rita K.3,

Affiliation:

1. Institute for Medical Informatics, Statistics and EpidemiologyUniversity of Leipzig Leipzig Germany

2. Institute of Human GeneticsRuprecht‐Karls University Heidelberg Germany

3. Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), Medical FacultyUniversity Hospital Cologne Cologne Germany

4. Department of GynaecologyRuprecht‐Karls University Heidelberg Germany

5. Department of Gynecology with Breast Center, Charité – Universitätsmedizin Berlin, Freie Universität BerlinHumboldt‐Universität zu Berlin, and Berlin Institute of Health Berlin Germany

6. Institute of Medical Genetics and Human Genetics, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität BerlinHumboldt‐Universität zu Berlin, and Berlin Institute of Health Berlin Germany

7. Department of RadiologyUniversity Hospital, LMU Munich Munich Germany

8. Department of Gynecology and ObstetricsUniversity Hospital Rechts der Isar, Technical University Munich Munich Germany

9. Department of Obstetrics and GynecologyUniversity Hospital and Medical Faculty of the Heinrich‐Heine University Duesseldorf Duesseldorf Germany

10. Department of Gynecology and ObstetricsUniversity Hospital of Schleswig‐Holstein, Christian‐Albrechts‐University Kiel Kiel Germany

11. Department of Gynecology and Obstetrics, Institute of Clinical Molecular BiologyUniversity Hospital of Schleswig‐Holstein, Christian‐Albrechts‐University Kiel Kiel Germany

12. Department of Gynecology and ObstetricsUlm University Hospital Ulm Germany

13. Institute of Human GeneticsUniversity of Ulm Ulm Germany

14. Institut für HumangenetikUniversitätsklinikum Münster Münster Germany

15. Institute of Clinical Radiology, Medical FacultyUniversity of Muenster, University Hospital Muenster Muenster Germany

16. Institute of Human GeneticsWürzburg University Würzburg Germany

17. Department of Obstetrics and GynecologyWürzburg University Hospital Würzburg Germany

18. Department of Human GeneticsHannover Medical School Hannover Germany

19. Department of Diagnostic and Interventional RadiologyHannover Medical School Hannover Germany

20. Department of Gynecology and Obstetrics, Medical Faculty and University Hospital Carl Gustav CarusTechnische Universität Dresden Dresden Germany

21. National Center for Tumor Diseases (NCT)Partner Site Dresden Dresden Germany

22. German Cancer Consortium (DKTK)Dresden and German Cancer Research Center (DKFZ) Heidelberg Germany

23. Department of Obstetrics and GynecologyUniversity Hospital Leipzig Leipzig Germany

Funder

German Cancer Aid

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference45 articles.

1. Meta-Analysis ofBRCA1andBRCA2Penetrance

2. Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers

3. Prevalence ofBRCA1/2germline mutations in 21 401 families with breast and ovarian cancer

4. Estimates of the gene frequency of BRCA1 and its contribution to breast and ovarian cancer incidence;Ford D;Am J Hum Genet,1995

5. Breast and ovarian cancer incidence in BRCA1‐mutation carriers. Breast cancer linkage consortium;Easton DF;Am J Hum Genet,1995

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