Gremlin 1 depletion in vivo causes severe enteropathy and bone marrow failure
Author:
Affiliation:
1. University College Dublin, School of Medicine and Conway Institute Dublin Ireland
2. University College Dublin, School of Veterinary Medicine Dublin Ireland
3. Intensive Care Unit Beacon Hospital Dublin Ireland
Funder
Health Research Board
Science Foundation Ireland
Publisher
Wiley
Subject
Pathology and Forensic Medicine
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/path.5450
Reference23 articles.
1. Microenvironmental regulation of stem cells in intestinal homeostasis and cancer
2. BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes
3. Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon
4. Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche
5. Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors
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