Biofactors regulating mitochondrial function and dynamics in podocytes and podocytopathies

Author:

Hejazian Seyyedeh Mina1,Ardalan Mohammadreza1ORCID,Hosseiniyan Khatibi Seyed Mahdi1,Rahbar Saadat Yalda1,Barzegari Abolfazl2ORCID,Gueguen Virginie2ORCID,Meddahi‐Pellé Anne2ORCID,Anagnostou Fani3ORCID,Zununi Vahed Sepideh1ORCID,Pavon‐Djavid Graciela2ORCID

Affiliation:

1. Kidney Research Center Tabriz University of Medical Sciences Tabriz Iran

2. Université Sorbonne Paris Nord, INSERM U1148, Laboratory for Vascular Translational Science Cardiovascular Bioengineering Villetaneuse France

3. Université de Paris, CNRS UMR 7052 INSERM U1271, B3OA Paris France

Abstract

AbstractPodocytes are terminally differentiated kidney cells acting as the main gatekeepers of the glomerular filtration barrier; hence, inhibiting proteinuria. Podocytopathies are classified as kidney diseases caused by podocyte damage. Different genetic and environmental risk factors can cause podocyte damage and death. Recent evidence shows that mitochondrial dysfunction also contributes to podocyte damage. Understanding alterations in mitochondrial metabolism and function in podocytopathies and whether altered mitochondrial homeostasis/dynamics is a cause or effect of podocyte damage are issues that need in‐depth studies. This review highlights the roles of mitochondria and their bioenergetics in podocytes. Then, factors/signalings that regulate mitochondria in podocytes are discussed. After that, the role of mitochondrial dysfunction is reviewed in podocyte injury and the development of different podocytopathies. Finally, the mitochondrial therapeutic targets are considered.

Funder

Tabriz University of Medical Sciences

Publisher

Wiley

Subject

Cell Biology,Clinical Biochemistry,Physiology

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