Affiliation:
1. State Key Laboratory of Silicon Materials School of Materials Science and Engineering Zhejiang University Hangzhou 310058 P.R. China
2. ZJU‐Hangzhou Global Scientific and Technological Innovation Center Hangzhou 311200 P. R. China
3. The Affiliated Hospital of Stomatology School of Stomatology Zhejiang University of Medicine Hangzhou 310006 P. R. China
4. College of Agriculture and Biotechnology Zhejiang University Hangzhou 310058 P. R. China
Abstract
AbstractThe combination of precise tumor depletion and immunotherapy presents great potential to exterminate cancer disease. Anaerobic bacteria can trigger innate and adaptive immune responses in tumors to facilitate the antitumor effects. However, bacteria injected intravenously induce systemic inflammation and are likely to be eliminated in the blood. Herein, live bacteria, Propionibacterium acnes (P. acnes), are integrated with ZnAl layered double hydroxides (LDHs) to construct an effective system enabling synergistic inhibition in both tumor growth and metastasis. In this system, P. acnes carries LDHs to reach and penetrate the hypoxic tumor tissue. The metabolism of colonized P. acnes and the pH‐responsive degradation of LDHs produce reactive nitrogen species and reactive oxygen species to trigger inevitable cell death. Furthermore, the decomposition of LDHs exposes P. acnes, and thus the immune response is activated to prohibit the reoccurrence of distant tumors. The biohybrid P. acnes@LDHs, developed in this study, possesses remarkable anticancer outcomes both in vitro and in vivo.
Funder
National Natural Science Foundation of China
Subject
Electrochemistry,Condensed Matter Physics,Biomaterials,Electronic, Optical and Magnetic Materials