Two-step enhanced cancer immunotherapy with engineered Salmonella typhimurium secreting heterologous flagellin-Reference-Cited by-同舟云学术

Two-step enhanced cancer immunotherapy with engineered Salmonella typhimurium secreting heterologous flagellin

Published:2017-02-08 Issue:376 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Zheng Jin Hai¹²,Nguyen Vu H.¹³,Jiang Sheng-Nan⁴⁵,Park Seung-Hwan⁶,Tan Wenzhi⁷,Hong Seol Hee⁸,Shin Myung Geun⁹,Chung Ik-Joo¹⁰,Hong Yeongjin⁷,Bom Hee-Seung⁴,Choy Hyon E.²⁷,Lee Shee Eun⁸,Rhee Joon Haeng²⁷,Min Jung-Joon¹²⁴⁷

Affiliation:

1. Laboratory of In Vivo Molecular Imaging, Institute for Molecular Imaging and Theranostics, Chonnam National University Hwasun Hospital, Jeonnam 58128, Republic of Korea.

2. Department of Molecular Medicine (BrainKorea21 Plus), Chonnam National University Graduate School, Gwangju 61469, Republic of Korea.

3. Department of Experimental Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.

4. Department of Nuclear Medicine, Chonnam National University Medical School, Gwangju 61469, Republic of Korea.

5. Department of Nuclear Medicine, Affiliated Haikou Hospital, Xiangya School of Medicine, Central South University, Hainan 570-208, China.

6. Biological Resource Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup 56212, Republic of Korea.

7. Department of Microbiology and Clinical Vaccine R&D Center, Chonnam National University Medical School, Gwangju 61469, Republic of Korea.

8. Department of Pharmacology and Dental Therapeutics, School of Dentistry, Chonnam National University, Gwangju 61186, Republic of Korea.

9. Department of Laboratory Medicine, Chonnam National University Medical School, Gwangju 61469, Republic of Korea.

10. Department of Hemato-Oncology, Chonnam National University Medical School, Jeonnam 58128, Republic of Korea.

Abstract

Engineered Salmonella secreting heterologous bacterial flagellin suppress tumor growth by activating intratumoral macrophages.

Funder

Pioneer Research Center Program

Bio & Medical Technology Development Program

National Research Foundation of Korea

Ministry of Science, ICT and Future Planning

NRF

Ministry of Health and Welfare, Republic of Korea

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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