Discovery of a Novel Amino Lipid That Improves Lipid Nanoparticle Performance through Specific Interactions with mRNA

Author:

Cornebise Mark1ORCID,Narayanan Elisabeth1,Xia Yan1,Acosta Edward1,Ci Lei1,Koch Hillary1,Milton Jaclyn1,Sabnis Staci1,Salerno Timothy1,Benenato Kerry E.1

Affiliation:

1. Moderna Therapeutics 200 Technology Square Cambridge MA 02319 USA

Publisher

Wiley

Subject

Electrochemistry,Condensed Matter Physics,Biomaterials,Electronic, Optical and Magnetic Materials

Reference44 articles.

1. Nanomaterial Delivery Systems for mRNA Vaccines

2. The challenge and prospect of mRNA therapeutics landscape

3. United States Food and Drug Administration. Pfizer COVID‐19 Vaccine EUA Letter of Authorization (Reissued December 23 2020 February 25 May 10 June 25 August 12 August 23 September 22 October 20 and October 29 2021) https://www.fda.gov/media/150386/download (accessed 2021‐02‐02).

4. United States Food and Drug Administration. Moderna COVID‐19 Vaccine EUA Letter of Authorization (Reissued February 25 July 7 August 12 and October 20 2021) https://www.fda.gov/media/144636/download (accessed 2021‐02‐02).

5. Enzyme entrapment in liposomes

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