Nanomaterial Delivery Systems for mRNA Vaccines-Reference-Cited by-同舟云学术

Nanomaterial Delivery Systems for mRNA Vaccines

Published:2021-01-19 Issue:1 Volume:9 Page:65
ISSN:2076-393X
Container-title:Vaccines
language:en
Short-container-title:Vaccines

Author:

Buschmann Michael D.^ORCID,Carrasco Manuel J.^ORCID,Alishetty Suman,Paige Mikell,Alameh Mohamad Gabriel^ORCID,Weissman Drew

Abstract

The recent success of mRNA vaccines in SARS-CoV-2 clinical trials is in part due to the development of lipid nanoparticle delivery systems that not only efficiently express the mRNA-encoded immunogen after intramuscular injection, but also play roles as adjuvants and in vaccine reactogenicity. We present an overview of mRNA delivery systems and then focus on the lipid nanoparticles used in the current SARS-CoV-2 vaccine clinical trials. The review concludes with an analysis of the determinants of the performance of lipid nanoparticles in mRNA vaccines.

Publisher

MDPI AG

Subject

Pharmacology (medical),Infectious Diseases,Drug Discovery,Pharmacology,Immunology

Link

https://www.mdpi.com/2076-393X/9/1/65/pdf

Reference173 articles.

1. Coronavirus Vaccine Tracker;Zimmer,2020

2. Moderna’s COVID-19 Vaccine Candidate Meets its Primary Efficacy Endpoint in the First Interim Analysis of the Phase 3 COVE Study|Moderna, Inchttps://investors.modernatx.com/news-releases/news-release-details/modernas-covid-19-vaccine-candidate-meets-its-primary-efficacy/

3. Pfizer and BioNTech Conclude Phase 3 Study of COVID-19 Vaccine Candidate, Meeting All Primary Efficacy Endpoints|BioNTechhttps://investors.biontech.de/news-releases/news-release-details/pfizer-and-biontech-conclude-phase-3-study-covid-19-vaccine/

4. Nanomedicines to Deliver mRNA: State of the Art and Future Perspectives

5. Tools for translation: non-viral materials for therapeutic mRNA delivery

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