Tumbler‐Inspired Microneedle Containing Robots: Achieving Rapid Self‐Orientation and Peristalsis‐Resistant Adhesion for Colonic Administration

Author:

Huang Libing1ORCID,Li Lihuang1,Jiang Yanjie1,Cai Jingfeng1,Cai Shuntian2,Ren Yandan2,Xu Hongzhi2,Luo Jingnan3,Wang Miao1ORCID,Ren Lei14ORCID

Affiliation:

1. The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province Department of Biomaterials Research Center of Biomedical Engineering of Xiamen College of Materials Xiamen University 422 Siming Nan Road Xiamen 361005 China

2. Department of Gastroenterology Zhongshan Hospital of Xiamen University Xiamen 361005 China

3. Junion Therapeutics (Xiamen) Co. Ltd. Xiamen 361005 China

4. State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China

Abstract

AbstractMicroneedle containing miniature robots offer a promising route for gastrointestinal administration since their capability of transmucosal delivery and controllable drug release. However, many challenges still lie ahead such as the intricate control modes, destitute systematic theory of the locomotion and adhesion behaviors, failure due to peristalsis and fluid flow, and risk of ileus. Herein, an untethered microneedle containing robots is designed for specific colonic administration, which can dispense with control systems, achieve fast self‐orientation and adhesion onto the mucosa (<0.6 s), against physiology of peristalsis, and show low risks of obstruction. Further, the detachable layer between the microneedle and the robots can degrade under a time of 6 min, which ensures safely discharge under a small, excreted force of 20 mN induced by fluid flow. Through the optimism of microneedles, different drug release times can be achieved including 14 min, 2 days, 4 days, and 30 days, respectively. The in vivo experiments also demonstrate the effectiveness and feasibility of the robots. These robots can serve as a versatile platform to treat diseases such as chronic inflammation and cancer of the colon to minimize invasive surgical intervention and patient suffering.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Electrochemistry,Condensed Matter Physics,Biomaterials,Electronic, Optical and Magnetic Materials

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