Affiliation:
1. Department of Radiology Zhongnan Hospital of Wuhan University Wuhan 430071 P. R. China
2. Department of Radiology Hainan General Hospital Haikou 570311 P. R. China
3. Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan University Wuhan 430071 P. R. China
4. School of Chemistry and Chemical Engineering Hubei University Wuhan 430071 P. R. China
Abstract
AbstractFerroptosis therapy induced by iron‐catalyzed Fenton reaction has offered enormous opportunities for tumor therapy. Unfortunately, high catalytic activity ferrous (Fe2+)‐based therapeutic agent has remained challenging due to the instability of Fe2+. Herein, an X‐ray‐activated Fe2+ supply platform, termed “PFCN”, containing the core of CaWO4 nanoscintillator to emit ultraviolet (UV) light and Fe3O4 decorated on the surface to deliver excessive Fe2+ is proposed. Under X‐ray excitation, the UV light emitted by CaWO4 can catalyze ferric (Fe3+) to generate Fe2+, which further cascades the Fenton reaction to induce highly toxic hydroxyl radicals generation. More importantly, immunogenic cell death‐associated immunotherapy is simultaneously triggered during this process. Experiments conducted in vitro and in vivo revealed that X‐ray‐triggered PFCN shows superior tumor therapeutic efficacy, contributing i) enhanced radiotherapy; ii) X‐ray‐activated ferroptosis therapy; and iii) ferroptosis/radiotherapy‐induced immunotherapy. Besides, PFCN can be utilized as an MR/CT dual‐mode imaging contrast agent for tumor diagnosis and treatment monitoring. The study provides a novel example of an X‐ray‐activated ferrous‐regeneration platform for imaging‐guided augmenting tumor ferroptosis/immunotherapy
Funder
National Natural Science Foundation of China
Natural Science Foundation of Hubei Province
Fundamental Research Funds for the Central Universities
Wuhan University
Subject
Electrochemistry,Condensed Matter Physics,Biomaterials,Electronic, Optical and Magnetic Materials
Cited by
4 articles.
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