Chondrocyte‐Specific RUNX2 Overexpression Accelerates Post‐traumatic Osteoarthritis Progression in Adult Mice-Reference-Cited by-同舟云学术

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Chondrocyte‐Specific RUNX2 Overexpression Accelerates Post‐traumatic Osteoarthritis Progression in Adult Mice

Published:2019-06-12 Issue:9 Volume:34 Page:1676-1689
ISSN:0884-0431
Container-title:Journal of Bone and Mineral Research
language:en
Short-container-title:J Bone Miner Res

Author:

Catheline Sarah E¹²,Hoak Donna¹³,Chang Martin¹³,Ketz John P¹³,Hilton Matthew J⁴,Zuscik Michael J¹³⁵⁶,Jonason Jennifer H¹³

Affiliation:

1. Center for Musculoskeletal Research University of Rochester Medical Center Rochester NY USA

2. Department of Pathology and Laboratory Medicine University of Rochester Medical Center Rochester NY USA

3. Department of Orthopaedics and Rehabilitation University of Rochester Medical Center Rochester NY USA

4. Department of Orthopaedic Surgery Duke University Durham NC USA

5. Department of Orthopedics University of Colorado Anschutz Medical Campus Aurora CO USA

6. Orthopedic Research Center University of Colorado Anschutz Medical Campus Aurora CO USA

Publisher

Wiley

Subject

Orthopedics and Sports Medicine,Endocrinology, Diabetes and Metabolism

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jbmr.3737

Reference90 articles.

1. The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6

2. L-Sox5 and Sox6 Drive Expression of the Aggrecan Gene in Cartilage by Securing Binding of Sox9 to a Far-Upstream Enhancer

3. SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene

4. SOX9 Governs Differentiation Stage-Specific Gene Expression in Growth Plate Chondrocytes via Direct Concomitant Transactivation and Repression

5. Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation

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