FGF18 encoding circular mRNA-LNP based on glycerolipid engineering of mesenchymal stem cells for efficient amelioration of osteoarthritis

Author:

Huang Ke12,Liu Xiaoyun3,Qin Haitang3,Li Yingwen4,Zhu Jiafeng4,Yin Bo5,Zheng Qijun12,Zuo Chijian4,Cao Hui3,Tong Zhenbo6ORCID,Sun Zhenhua4

Affiliation:

1. Department of Chemical and Biological Engineering, Monash University, Clayton, VIC 3800, Australia

2. Suzhou Industrial Park Monash Research Institute of Science and Technology, Suzhou, 215000, China

3. Jiangsu Purecell Biopharma Technology Co., Ltd, Suzhou 215125, China

4. Suzhou CureMed Biopharma Technology Co., Ltd, Suzhou 215125, China

5. National University of Singapore (Suzhou) Research Institute, Suzhou, 215123, China

6. Southeast University-Monash University Joint Research Institute, Suzhou 215125, China

Abstract

TG6A-LNP loading with FGF18 circular mRNA-engineered mesenchymal stem cells for healing of osteoarthritis.

Publisher

Royal Society of Chemistry (RSC)

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