Association of brain microbleeds with risk factors, cognition, and MRI markers in MESA

Author:

Jensen Paul N.12,Rashid Tanweer3,Ware Jeffrey B.4,Cui Yuhan5,Sitlani Colleen M.12,Austin Thomas R.16,Longstreth W. T.67,Bertoni Alain G.8,Mamourian Elizabeth45,Bryan R. Nick4,Nasrallah Ilya M.45,Habes Mohamad35,Heckbert Susan R.16ORCID

Affiliation:

1. Cardiovascular Health Research Unit University of Washington Seattle Washington USA

2. Department of Medicine University of Washington Seattle Washington USA

3. Neuroimage Analytics Laboratory and Biggs Institute Neuroimaging Core Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases University of Texas Health Science Center San Antonio San Antonio Texas USA

4. Department of Radiology Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA

5. Center for AI and Data Science for Integrated Diagnostics and Center for Biomedical Image Computing and Analytics University of Pennsylvania Philadelphia Pennsylvania USA

6. Department of Epidemiology University of Washington Seattle Washington USA

7. Department of Neurology University of Washington Seattle Washington USA

8. Department of Internal Medicine Wake Forest School of Medicine Winston‐Salem North Carolina USA

Abstract

AbstractINTRODUCTIONLittle is known about the epidemiology of brain microbleeds in racially/ethnically diverse populations.METHODSIn the Multi‐Ethnic Study of Atherosclerosis, brain microbleeds were identified from 3T magnetic resonance imaging susceptibility‐weighted imaging sequences using deep learning models followed by radiologist review.RESULTSAmong 1016 participants without prior stroke (25% Black, 15% Chinese, 19% Hispanic, 41% White, mean age 72), microbleed prevalence was 20% at age 60 to 64.9 and 45% at ≥85 years. Deep microbleeds were associated with older age, hypertension, higher body mass index, and atrial fibrillation, and lobar microbleeds with male sex and atrial fibrillation. Overall, microbleeds were associated with greater white matter hyperintensity volume and lower total white matter fractional anisotropy.DISCUSSIONResults suggest differing associations for lobar versus deep locations. Sensitive microbleed quantification will facilitate future longitudinal studies of their potential role as an early indicator of vascular pathology.

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3