Fitting Emax models to clinical trial dose-response data when the high dose asymptote is ill defined
Author:
Affiliation:
1. School of Mathematics, Statistics and Actuarial Science; University of Kent; Canterbury, Kent UK
2. Department of Statistics; Neusentis; Cambridge, Cambridgeshire UK
3. School of Mathematics; University of Cardiff; Cardiff, Glamorgan UK
Publisher
Wiley
Subject
Pharmacology (medical),Pharmacology,Statistics and Probability
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/pst.1636/fullpdf
Reference11 articles.
1. Fitting Emax models to clinical trial dose-response data;Kirby;Pharmaceutical Statistics,2011
2. Hypothesis testing and Bayesian estimation using a Sigmoid Emax model applied to sparse dose-response designs;Thomas;Journal Of Biopharmaceutical Statistics,2006
3. Asymptotic properties of non-linear least squares estimators;Jennrich;Annals of Mathematical Statistics,1969
4. A Comparison of three methods for calculating confidence. Intervals for the benchmark dose;Moerbeek;Risk Analysis,2004
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