The inhibition of several components of terminal complement pathway results in C3 binding to PNH red blood cells
Author:
Affiliation:
1. Laboratory of Cancer Genetics and Gene Transfer, Core Research Laboratory Istituto per lo Studio, la Prevenzione e la Rete Oncologica (ISPRO) Florence Italy
Funder
Istituto Toscano Tumori
Publisher
Wiley
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajh.27215
Reference12 articles.
1. Long‐term safety and efficacy of sustained eculizumab treatment in patients with paroxysmal nocturnal haemoglobinuria
2. Long‐term safety and efficacy of ravulizumab in patients with paroxysmal nocturnal hemoglobinuria: 2‐year results from two pivotal phase 3 studies
3. Eculizumab treatment: stochastic occurrence of C3 binding to individual PNH erythrocytes
4. Complement fraction 3 binding on erythrocytes as additional mechanism of disease in paroxysmal nocturnal hemoglobinuria patients treated by eculizumab
5. The long‐acting anti‐C5 ravulizumab results in C3 binding to PNH red cells similar to its parental molecule eculizumab
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