Glutathione carbon dots as an intracellular reactive oxygen species scavenger for reducing cisplatin‐induced ototoxicity

Author:

Tu Yaqin1,Fan Guorun1,Wu Nan1,Liu Bo1,Sun Haiying1,Wang Qiong2,Zou Wenqing1,Xiao Hongjun1ORCID,Tan Songwei3

Affiliation:

1. Department of Otorhinolaryngology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan P. R. China

2. Cancer Center/Institute of Radiation Oncology/Hubei Key Laboratory of Precision Radiation Oncology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan P. R. China

3. School of Pharmacy Tongji Medical College Huazhong University of Science and Technology Wuhan P. R. China

Abstract

AbstractIt is widely recognized that platinum‐based chemotherapy, particularly cisplatin therapy, can cause ototoxicity. At present, there are no Food and Drug Administration‐approved drugs to prevent or alleviate ototoxicity. Ototoxicity is generally believed to be caused by excessive reactive oxygen species production in the inner ear. Accordingly, a variety of antioxidants have been developed to protect against ototoxicity. To improve the efficiency of drug delivery to the cochlea, here, we synthesized simple and easy‐to‐obtain glutathione carbon dots (GSH CDs) with ultra‐small dimensions. The experimental results revealed that the GSH CDs have strong free‐radical scavenging activity and can restore mitochondrial function, maintain hair cell stability, and protect hair cells from cisplatin‐induced oxidative stress. Thus, GSH CDs may serve as a new therapeutic agent for preventing cisplatin‐induced ototoxicity.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Biomedical Engineering,Biomaterials

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