Verapamil hepatic clearance in four preclinical rat models: towards activity-based scaling-Reference-Cited by-同舟云学术

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Verapamil hepatic clearance in four preclinical rat models: towards activity-based scaling

Published:2015-06-11 Issue:7 Volume:36 Page:462-480
ISSN:0142-2782
Container-title:Biopharmaceutics & Drug Disposition
language:en
Short-container-title:Biopharm. Drug Dispos.

Author:

Nicolaï J.¹,De Bruyn T.¹,Van Veldhoven P. P.²,Keemink J.¹,Augustijns P.¹,Annaert P.¹

Affiliation:

1. Drug Delivery and Disposition; KU Leuven Department of Pharmaceutical and Pharmacological Sciences, O&N2; Leuven Belgium

2. Laboratory of Lipid Biochemistry and Protein Interactions; KU Leuven Department of Cellular and Molecular Medicine, O&N1; Leuven Belgium

Funder

Innovation by Science and Technology

Laboratory for Drug Delivery and Disposition

KU Leuven Department of Pharmaceutical

Pharmacological Sciences

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology,General Medicine

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/bdd.1959/fullpdf

Reference49 articles.

1. Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance;Houston;Biochem Pharmacol,1994

2. Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design;Di;Eur J Med Chem,2012

3. The pivotal role of hepatocytes in drug discovery;Soars;Chem Biol Interact,2007

4. Comparison of intrinsic clearance in liver microsomes and hepatocytes from rats and humans: evaluation of free fraction and uptake in hepatocytes;Lu;Drug Metab Dispos,2006

5. Evaluation of cryopreserved human hepatocytes as an alternative in vitro system to microsomes for the prediction of metabolic clearance;Brown;Drug Metab Dispos,2007

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