Affiliation:
1. Marchuk Institute of Numerical Mathematics of the Russian Academy of Sciences Moscow Russia
2. Sirius University of Science and Technology Sochi Russia
3. Sechenov University Moscow Russia
Abstract
AbstractIn this work, we develop numerical methods for the solution of blood flow and coagulation on dynamic adaptive moving meshes. We consider the blood flow as a flow of incompressible Newtonian fluid governed by the Navier–Stokes equations. The blood coagulation is introduced through the additional Darcy term, with a permeability coefficient dependent on reactions. To this end, we introduce moving mesh collocated finite‐volume methods for the Navier–Stokes equations, advection–diffusion equations, and a method for the stiff cascade of reactions. A monolithic nonlinear system is solved to advance the solution in time. The finite volume method for the Navier–Stokes equations features collocated arrangement of pressure and velocity unknowns and a coupled momentum and mass flux. The method is conservative and inf‐sup stable despite the saddle point nature of the system. It is verified on a series of analytical problems and applied to the blood flow problem in the deforming domain of the right ventricle, reconstructed from a time series of computed tomography scans. At last, we demonstrate the ability to model the coagulation process in deforming microfluidic capillaries.
Funder
Ministry of Education and Science of the Russian Federation
Russian Science Foundation
Subject
Applied Mathematics,Computational Theory and Mathematics,Molecular Biology,Modeling and Simulation,Biomedical Engineering,Software
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献