Computational de novo design of antibodies binding to a peptide with high affinity-Reference-Cited by-同舟云学术

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Computational de novo design of antibodies binding to a peptide with high affinity

Published:2017-02-02 Issue:6 Volume:114 Page:1331-1342
ISSN:0006-3592
Container-title:Biotechnology and Bioengineering
language:en
Short-container-title:Biotechnol. Bioeng.

Author:

Poosarla Venkata Giridhar¹²,Li Tong¹,Goh Boon Chong³,Schulten Klaus³,Wood Thomas K.¹²,Maranas Costas D.¹

Affiliation:

1. Department of Chemical EngineeringUniversity ParkPennsylvania16802

2. Department of Biochemistry and Molecular BiologyPennsylvania State UniversityUniversity ParkPennsylvania16802

3. Department of Physics and Beckman InstituteUniversity of Illinois at Urbana‐ChampaignUrbanaIllinois61801

Funder

National Science Foundation

National Institutes of Health

Publisher

Wiley

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bit.26244

Reference41 articles.

1. Basic local alignment search tool

2. Efficient production of single-chain fragment variable-based N-terminal trimerbodies in Pichia pastoris

3. Large-scale analysis of somatic hypermutations in antibodies reveals which structural regions, positions and amino acids are modified to improve affinity

4. The association of heavy and light chain variable domains in antibodies: implications for antigen specificity

5. Trends in Antibody Sequence Changes during the Somatic Hypermutation Process

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