Large-scale analysis of somatic hypermutations in antibodies reveals which structural regions, positions and amino acids are modified to improve affinity
Author:
Affiliation:
1. The Goodman Faculty of Life Sciences; Bar Ilan University; Ramat Gan Israel
Publisher
Wiley
Subject
Cell Biology,Molecular Biology,Biochemistry
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/febs.12597/fullpdf
Reference54 articles.
1. Immunoglobulin gene diversification;Maizels;Annu Rev Genet,2005
2. Molecular mechanisms of antibody somatic hypermutation;Noia;Annu Rev Biochem,2007
3. Clonal selection and learning in the antibody system;Rajewsky;Nature,1996
4. A germline knowledge based computational approach for determining antibody complementarity determining regions;Zhao;Mol Immunol,2010
5. The generation of antibody diversity through somatic hypermutation and class switch recombination;Li;Genes Dev,2004
Cited by 41 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Unveiling the multifaceted landscape of N-glycosylation in antibody variable domains: Insights and implications;International Journal of Biological Macromolecules;2024-02
2. Developing similarity matrices for antibody-protein binding interactions;PLOS ONE;2023-10-26
3. “Redirecting an anti-IL-1β antibody to bind a new, unrelated and computationally predicted epitope on hIL-17A”;Communications Biology;2023-09-29
4. Accurate profiling of full-length Fv in highly homologous antibody libraries using UMI tagged short reads;Nucleic Acids Research;2023-04-04
5. Heavy chain‐only antibody genes in fish evolved to generate unique CDR3 repertoire;European Journal of Immunology;2021-11-19
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3