GAS6-expressing and self-sustaining cancer cells in 3D spheroids activate the PDK-RSK-mTOR pathway for survival and drug resistance-Reference-Cited by-同舟云学术

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GAS6-expressing and self-sustaining cancer cells in 3D spheroids activate the PDK-RSK-mTOR pathway for survival and drug resistance

Published:2017-07-26 Issue:10 Volume:11 Page:1430-1447
ISSN:1574-7891
Container-title:Molecular Oncology
language:en
Short-container-title:Mol Oncol

Author:

Baumann Christine¹,Ullrich Axel¹,Torka Robert¹²^ORCID

Affiliation:

1. Department of Molecular Biology; Max-Planck-Institute of Biochemistry; Martinsried Germany

2. Institute of Physiological Chemistry; University Halle-Wittenberg; Halle (Saale) Germany

Funder

Max-Planck-Gesellschaft

Publisher

Wiley

Subject

Cancer Research,Genetics,Molecular Medicine,General Medicine,Oncology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/1878-0261.12109/fullpdf

Reference36 articles.

1. Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-cells;Andreozzi;Endocrinology,2004

2. MKNK1 is a YB-1 target gene responsible for imparting trastuzumab resistance and can be blocked by RSK inhibition;Astanehe;Oncogene,2012

3. Cross-phosphorylation, signaling and proliferative functions of the Tyro3 and Axl receptors in Rat2 cells;Brown;PLoS ONE,2012

4. Cancer stem cells-perspectives on current status and future directions: AACR Workshop on cancer stem cells;Clarke;Can Res,2006

5. YB-1 evokes susceptibility to cancer through cytokinesis failure, mitotic dysfunction and HER2 amplification;Davies;Oncogene,2011

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