Overexpression of Tpl2 is linked to imatinib resistance and activation of MEK ‐ ERK and NF ‐κB pathways in a model of chronic myeloid leukemia

Author:

Chorzalska Anna1,Ahsan Nagib2ORCID,Rao R. Shyama Prasad3ORCID,Roder Karim4,Yu Xiaoqing5,Morgan John6,Tepper Alexander1,Hines Steven1,Zhang Peng4,Treaba Diana O.7ORCID,Zhao Ting C.8,Olszewski Adam J.9ORCID,Reagan John L.9ORCID,Liang Olin9ORCID,Gruppuso Philip A.10ORCID,Dubielecka Patrycja M.1ORCID

Affiliation:

1. Signal Transduction Lab Division of Hematology/Oncology Rhode Island Hospital Warren Alpert Medical School Brown University Providence RI USA

2. Division of Biology and Medicine COBRE CCRD Proteomics Core Facility Rhode Island Hospital Brown University Providence RI USA

3. Division of Biostatistics and Bioinformatics Yenepoya Research Center Yenepoya University Mangalore India

4. Cardiovascular Research Center Rhode Island Hospital Warren Alpert Medical School Brown University Providence RI USA

5. Department of Biostatistics Yale School of Public Health New Haven CT USA

6. Flow Cytometry and Cell Sorting Core Facility Roger Williams Medical Center Providence RI USA

7. Department of Pathology and Laboratory Medicine Rhode Island Hospital Warren Alpert Medical School Brown University Providence RI USA

8. Cardiovascular Lab Department of Surgery Roger Williams Medical Center Boston University School of Medicine Providence RI USA

9. Division of Hematology/Oncology Rhode Island Hospital Warren Alpert Medical School Brown University Providence RI USA

10. Department of Pediatrics Rhode Island Hospital Brown University Providence RI USA

Funder

National Institutes of Health

Publisher

Wiley

Subject

Cancer Research,Genetics,Molecular Medicine,General Medicine,Oncology

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