Diphenhydramine increases the therapeutic window for platinum drugs by simultaneously sensitizing tumor cells and protecting normal cells

Author:

Melnikova Margarita1,Wauer Ulrike Sophie234,Mendus Diana1,Hilger Ralf Axel5,Oliver Trudy G.6,Mercer Kim6,Gohlke Björn Oliver7,Erdmann Kati348ORCID,Niederacher Dieter9,Neubauer Hans9,Buderath Paul10,Wimberger Pauline234ORCID,Kuhlmann Jan Dominik234ORCID,Thomale Jürgen1ORCID

Affiliation:

1. Institute of Cell Biology (Cancer Research) University of Duisburg‐Essen Medical School Germany

2. Department of Gynecology and Obstetrics Medical Faculty and University Hospital Carl Gustav Carus Technische Universität Dresden Germany

3. National Center for Tumor Diseases (NCT), Dresden, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Helmholtz‐Zentrum Dresden ‐ Rossendorf (HZDR) Dresden Germany

4. German Cancer Consortium (DKTK)Dresden and German Cancer Research Center (DKFZ) Heidelberg Germany

5. West German Cancer Center University Hospital Essen Germany

6. Massachusetts Institute of Technology Cambridge MA USA

7. Structural Bioinformatics Group Institute for Physiology Charité – University Medicine Berlin Germany

8. Department of Urology Medical Faculty and University Hospital Carl Gustav Carus Technische Universität Dresden Germany

9. Department of Obstetrics and Gynecology University Hospital and Medical Faculty of the Heinrich Heine University Düsseldorf Germany

10. Department of Gynecology and Obstetrics University Hospital Essen Germany

Publisher

Wiley

Subject

Cancer Research,Genetics,Molecular Medicine,General Medicine,Oncology

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